Fig 1. A haploid genetic screen for resistance to T cell mediated killing.

A) Experimental scheme: A library of gene trap-mutagenized haploid HAP1 cells was generated, in which most cells harbor irrelevant mutations (red) and rare cells harbor mutations that reduce their sensitivity towards T cell killing (green). Upon exposure to T cells (depicted in blue), cells with reduced sensitivity are positively selected and, following expansion, integration sites in the surviving cell population are analyzed. B) List of most significantly enriched hits. Yellow: components of the IFNGR signaling pathway; green: SLFN11.