Table 3.

Thresholds, Membrane Currents, Timing, and Action Potentials in Three Models

		Tested Subthresholda	Threshold	Tested Suprathreshold 1	Tested Suprathreshold 2
HH #1	laser intensity [W ⋅ cm–2]	150	186	190	230
	action potential peak time (ms)	N/A	0.14	0.12	0.080 (1st)b
					0.53 (2nd)
	inward TRPV1 current peak time (ms)	N/A	0.12	0.11	0.065 (1st)b
					0.50 (2nd)b
	inward capacitive current peak time (ms)	0.0	0.0	0.0	0.075 (1st)b
					0.52 (2nd)b
	maximal initial inward TRPV1 current (A ⋅ m–2)	N/Ac	0.035	0.035	0.034 (1st)b
					0.045 (2nd)b
	maximal initial inward capacitive current (A ⋅ m–2)	0.0079	0.0095	0.0096	0.011
HH #2	laser intensity (W ⋅ cm–2)	200	234	240	280
	action potential peak time (ms)	N/A	0.17	0.14	0.11 (1st)b
					0.51 (2nd)b
	inward TRPV1 current peak time (ms)	N/A	0.165	0.13	0.095 (1st)b
					0.49 (2nd)b
	maximal initial inward TRPV1 current (A ⋅ m–2)	N/Ac	0.038	0.037	0.037 (1st)b
					0.050 (2nd)b
HH #3	laser intensity (W ⋅ cm–2)	490	519	530	570
	action potential peak time (ms)	N/A	0.11	0.075	0.060
	inward capacitive current peak time (ms)	0.0	0.0	0.0	0.055
	maximal initial inward capacitive current (A ⋅ m–2)	0.021	0.023	0.023	0.025

^aThe peak time in this table represents the time from the onset of laser stimulation.^bIn the case of multiple action potentials, their corresponding timings and currents are listed as first and second in chronological order.

^cWe defined the maximal initial inward TRPV1 current as the maximal value in the time range between the stimulation onset and the action potential, so it is not applicable to the subthreshold cases, although the TRPV1 current continuously increased during the stimulation period.