Table 2.

Empirical Type I Error Rates of SMMAT-B, SMMAT-S, SMMAT-O, and SMMAT-E Assuming All Studies in the Same Group (hom) and Scenario A, B, C, and D Studies in Four Separate Groups (het), in Meta-analysis Simulation Studies at Significance Levels of 0.05, 0.0001, and 2.5 × 10⁻⁶

	Continuous Traits			Binary Traits
Level	0.05	0.0001	2.5 × 10−6	0.05	0.0001	2.5 × 10−6
SMMAT-B	0.051	1.0 × 10−4	2.6 × 10−6	0.051	1.1 × 10−4	2.5 × 10−6
Hom SMMAT-S	0.051	1.0 × 10−4	2.6 × 10−6	0.051	1.1 × 10−4	2.1 × 10−6
Het SMMAT-S	0.051	1.0 × 10−4	2.8 × 10−6	0.052	1.0 × 10−4	2.4 × 10−6
Hom SMMAT-O	0.053	1.3 × 10−4	4.0 × 10−6	0.053	1.4 × 10−4	3.4 × 10−6
Het SMMAT-O	0.052	1.1 × 10−4	2.6 × 10−6	0.052	1.1 × 10−4	2.2 × 10−6
Hom SMMAT-E	0.051	1.0 × 10−4	2.5 × 10−6	0.051	1.1 × 10−4	2.6 × 10−6
Het SMMAT-E	0.051	1.0 × 10−4	2.8 × 10−6	0.052	1.1 × 10−4	3.0 × 10−6

The total sample size was 12,000 from 12 studies, and results from 4,000 simulation replicates were combined to get 40 million genetic variant sets.