Table 3.
TOPMed Fibrinogen-Level SMMAT p Values in Known Association Gene FGB and Flanking Regions on Chromosome 4, using a Heteroscedastic Linear Mixed Model on Rare Variants with MAF < 5% (n = 23,763)
| Start (kb) | End (kb) | No. of Variants | SMMAT-B | SMMAT-S | SMMAT-O | SMMAT-E |
|---|---|---|---|---|---|---|
| 154,554 | 154,558 | 348 | 6.9 × 10−5 | 1.6 × 10−17 | 8.9 × 10−17 | 6.2 × 10−19 |
| 154,558 | 154,562 | 370 | 0.078 | 3.7 × 10−11 | 2.4 × 10−10 | 3.7 × 10−14 |
| 154,562 | 154,566 | 326 | 0.76 | 1.5 × 10−9 | 3.5 × 10−9 | 4.2 × 10−10 |
| 154,566 | 154,570 | 309 | 1.6 × 10−8 | 9.7 × 10−17 | 3.3 × 10−16 | 3.1 × 10−17 |
| 154,570 | 154,574 | 332 | 0.030 | 1.9 × 10−7 | 5.2 × 10−7 | 8.9 × 10−8 |
| 154,574 | 154,578 | 349 | 2.1 × 10−7 | 7.3 × 10−7 | 2.8 × 10−7 | 4.1 × 10−13 |
| 154,578 | 154,582 | 342 | 1.7 × 10−4 | 2.7 × 10−5 | 2.8 × 10−5 | 2.1 × 10−9 |
Physical positions of each window are on build hg38.