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Prochelator GGTDTC uses a p-amidobenzyl linker (PAB, black) to connect a dithiocarbamate (DTC, red) pharmacophore to a γ-linked glutamic acid. Recognition by the GGT enzyme results in transpeptidation to release γ-GluGlyGly and via 1,6-benzyl elimination of the linker, DTC that is then available to bind copper.
