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. Author manuscript; available in PMC: 2020 Mar 15.
Published in final edited form as: Brain Res. 2018 Nov 27;1707:198–207. doi: 10.1016/j.brainres.2018.11.039

Fig.5:

Fig.5:

A schematic shows potential interaction of miR-146a increased by Tβ4 with its target genes and downstream pro-inflammatory proteins. Diabetic peripheral neuropathy down-regulates miR-146a, upregulates IRAK1 and TRAF6, and activates downstream NFkB. Tβ4-elevated miR-146a represses IRAK1 and TRAF6, which results in attenuation of NFkB activation and pro-inflammatory genes VCAM-1 and MCP-1.