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. 2018 Apr 18;24(8):1206–1219. doi: 10.1038/s41380-018-0034-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Deficient LTD and increased LTP with conditional deletion of PirB in forebrain excitatory neurons. a LTP at CA3-CA1 synapses in CamKIIa-Cre; PirB + / + (Pyr-WT) vs. CamKIIa-Cre; PirB fl/fl (Pyr-KO) induced with 4 × 100 Hz. Pyr-WT LTP: 146.19 ± 1.3 % (n = 8 slices/5 mice). Pyr-KO LTP: 180.7 ± 1.35 % (n = 8 slices/3 mice); p < 0.001. b LTD induced with 900 pulses at 1 Hz. Pyr-WT LTD: 83.9 ± 0.65 % (n = 12 slices/6 mice) vs. Pyr-KO LTD: 110.4 ± 0.61 % (n = 16 slices/6 mice); p < 0.001. c Same as (b), but LTD induction using 0.5 Hz. Pyr-WT LTD 0.5 Hz: 93.7 ± 1.15 % (n = 9 slices/5 mice) vs. Pyr-KO LTD 0.5 Hz: 104.8 ± 1.08 % (n = 5 slices/3 mice); p < 0.001. d Summary of LTP and LTD vs. the frequency of induction in Pyr-WT vs. Pyr-KO. Absence of LTD in Pyr-KO is evident for a range of frequencies from 0.5 to 400 Hz. e Bar-graphs of average paired-pulse ratios (PPR). Pyr-WT LTD: 1.10 ± 0.01 (n = 12 slices, 6 mice) vs. Pyr-KO LTD: 0.970 ± 0.003 (n = 16 slices, 6 mice); p < 0.001. Pyr-WT LTP: 0.999 ± 0.16 (n = 8 slices, 5 mice) vs. Pyr-KO LTP: 0.927 ± 0.004 (n = 8 slices, 3 mice), p < 0.001, ***p < 0.001. Test: 2-Way RM Anova. Mean values are averages of fEPSP slopes or PPR measured between 20–90 min post-induction. Insets: fEPSP trace examples from Pyr-WT and Pyr-KO slices before (gray line) and after induction (black line) of LTP (a) or LTD (b, c); each trace is average of 30 individual traces taken at baseline or 75–90 min post-induction.