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Onium chalcogen effects for methyltransferase activity of PchF-FL and PchF-AMT.
| Enzyme | Substrate | kcat (min−1) | KM (μM) | kcat/KM (M−1s−1) |
|---|---|---|---|---|
| PchF-FL | AdoMet | 1.2 ± 0.1 | 3.3 ± 0.8 | 6000 ± 2000 |
| SeAdoMet | 2.3 ± 0.6 | 3 ± 1 | 13000 ± 5000 | |
| TeAdoMet | 0.056 ± 0.003 | 160 ± 10 | 6.0 ± 0.5 | |
| PchF-AMT | AdoMet | 2.48 ± 0.04 | 7.3 ± 0.8 | 5700 ± 600 |
| SeAdoMet | 5.4 ± 0.8 | 5.4 ± 0.5 | 17000 ± 3000 | |
| TeAdoMet | 0.054± 0.003 | 140 ± 20 | 7 ± 1 |
