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. 2019 Feb 13;2019(2):CD007412. doi: 10.1002/14651858.CD007412.pub5

Comparison 9. Active versus mixed management (uterotonic after placental delivery, immediate cord clamping and no controlled cord traction)  .

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Severe primary PPH at time of birth (clinically estimated or measured blood loss ≥ 1000 mL) 1 1648 Risk Ratio (M‐H, Random, 95% CI) 0.23 [0.09, 0.55]
1.1 Higher‐income setting 1 1648 Risk Ratio (M‐H, Random, 95% CI) 0.23 [0.09, 0.55]
1.2 Lower‐income setting 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
2 Very severe primary PPH at time of birth (clinically estimated or measured blood loss ≥ 2500 mL) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
2.1 Higher‐income setting 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
2.2 Lower‐income setting 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
3 Maternal mortality 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
3.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
3.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
4 Maternal Hb < 9 g/dL at 24‐72 hr 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
4.1 Higher‐income setting 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
4.2 Lower‐income setting 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
5 Admission to neonatal special/intensive care 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
5.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
5.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
6 Neonatal jaundice requiring phototherapy or exchange transfusion 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
6.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
6.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
7 Neonatal polycythaemia treated with dilutional exchange transfusion 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
7.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
7.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
8 Severe primary PPH after placental delivery and up to 24 hours (clinically estimated or measured blood loss ≥ 1000 mL) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
8.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
8.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
9 Severe primary PPH at time of birth and up to 24 hours (clinically estimated or measured blood loss ≥1000 mL) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
9.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
9.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
10 Primary blood loss ≥ 500 mL at time of birth (clinically estimated or measured) 1 1648 Risk Ratio (M‐H, Random, 95% CI) 0.53 [0.38, 0.74]
10.1 Higher‐income setting 1 1648 Risk Ratio (M‐H, Random, 95% CI) 0.53 [0.38, 0.74]
10.2 Lower‐income setting 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
11 Primary blood loss ≥ 500 mL after delivery of placenta and up to 24 hours (clinically estimated or measured) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
11.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
11.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
12 Primary blood loss ≥ 500 mL at time of birth and up to 24 hours (clinically estimated or measured) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
12.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
12.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
13 Mean maternal blood loss (mL) at time of birth (clinically estimated or measured) 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13.1 Higher‐income setting  0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
13.2 Lower‐income setting  0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
14 Mean maternal blood loss (mL) after delivery of placenta and up to 24 hours (clinically estimated or measured) 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
14.1 Higher‐income setting  0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
14.2 Lower‐income setting  0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
15 Mean maternal blood loss (mL) at time of birth and up to 24 hours (clinically estimated or measured) 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
15.1 Higher‐income setting  0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
15.2 Lower‐income setting  0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
16 Maternal blood transfusion 1 1648 Risk Ratio (M‐H, Random, 95% CI) 0.25 [0.03, 2.22]
16.1 Higher‐income setting 1 1648 Risk Ratio (M‐H, Random, 95% CI) 0.25 [0.03, 2.22]
16.2 Lower‐income setting 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
17 Clinical signs of severe blood loss 1 1648 Risk Ratio (M‐H, Random, 95% CI) 0.25 [0.05, 1.17]
17.1 Higher‐income setting  1 1648 Risk Ratio (M‐H, Random, 95% CI) 0.25 [0.05, 1.17]
17.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
18 Therapeutic uterotonics during third stage and/or within 24 hours 1 1648 Risk Ratio (M‐H, Random, 95% CI) 0.45 [0.26, 0.77]
18.1 Higher‐income setting 1 1648 Risk Ratio (M‐H, Random, 95% CI) 0.45 [0.26, 0.77]
18.2 Lower‐income setting 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
19 Mean length of third stage 1 1648 Mean Difference (IV, Random, 95% CI) ‐10.0 [‐10.24, ‐9.76]
19.1 Higher‐income setting 1 1648 Mean Difference (IV, Random, 95% CI) ‐10.0 [‐10.24, ‐9.76]
19.2 Lower‐income setting 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
20 Manual removal of placenta as defined by study authors 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
20.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
20.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
21 Postnatal diastolic blood pressure > 90 mmHg between birth of baby and discharge from the labour ward 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
21.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
21.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
22 Postnatal vomiting between birth of baby and discharge from the labour ward 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
22.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
22.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
23 Any analgesia between birth of the baby and discharge from labour ward 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
23.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
23.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
24 Women's assessment of pain during third stage as reported by study authors 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
24.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
24.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
25 Secondary blood loss/any vaginal bleeding needing treatment (after 24 hours and up to 6 weeks) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
25.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
25.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
26 Amount of lochia either estimated or measured after 24 hours and up to discharge from hospital 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
26.1 Higher‐income setting  0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
26.2 Lower‐income setting  0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
27 Surgical evacuation of retained products of conception 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
27.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
27.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
28 Afterpains ‐ abdominal pain associated with the contracting uterus in the postpartum period 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
28.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
28.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
29 Apgar score < 7 at 5 minutes 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
29.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
29.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
30 Birthweight 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
30.1 Higher‐income setting  0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
30.2 Lower‐income setting  0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
31 Neonatal encephalopathy assessed using Sarnat staging (Sarnat 1976; Table 1) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
31.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
31.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
32 Neonatal mortality 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
32.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
32.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
33 Intraventricular haemorrhage ‐ Papille grade III/IV ‐ (for infants born before 34 weeks' gestation only) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
33.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
33.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
34 Number of infants who received a red blood cell transfusion 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
34.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
34.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
35 Infant Hb level at 24 to 72 hours 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
35.1 Higher‐income setting  0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
35.2 Lower‐income setting  0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
36 Infant Hb level at 3‐6 months 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
36.1 Higher‐income setting  0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
36.2 Lower‐income setting  0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
37 Infant iron indices (ferritin) at 3 to 6 months 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
37.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
37.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
38 Exclusive breastfeeding at discharge from hospital 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
38.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
38.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
39 Neurodevelopmental, cognitive or developmental outcomes assessed after age 18 months 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
39.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
39.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
40 Return to hospital as in‐ or outpatient because of bleeding (not pre‐specified) 0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
40.1 Higher‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
40.2 Lower‐income setting  0 0 Risk Ratio (M‐H, Random, 95% CI) 0.0 [0.0, 0.0]
41 Postnatal maternal mean Hb (outcome not pre‐specified) 0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
41.1 Higher‐income setting  0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
41.2 Lower‐income setting  0 0 Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]