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. 2018 Oct 10;38(9):1489–1507. doi: 10.1038/s41388-018-0532-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Hsp90ab1 expression was positively associated with progression and poor prognosis and could be an independent prognostic factor for GC patients. a IHC analysis of Hsp90ab1 expression in GC tissue samples (T) and surrounding non-tumor tissues (N). The representative figures of GC tissues with low and high Hsp90ab1 levels of the staining intensity were shown. b Graphical illustration of statistical Hsp90ab1 distribution in GC tissues. Hsp90ab1 was significantly higher in GC than their adjacent nontumorous tissues. Hsp90ab1 protein expression was more frequently found in GC with AJCC classification (III/IV) than that with AJCC classification (I/II). Also Hsp90ab1 protein expression was more frequently found in GC with lymph node metastasis, vascular invasion than that in GC without lymph node metastasis, vascular invasion. c Kaplan–Meier survival analysis for GC patients with distinct expression level of Hsp90ab1 and AJCC classification after surgical resection