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. 2018 Oct 10;38(9):1489–1507. doi: 10.1038/s41388-018-0532-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Overexpression of Hsp90ab1 promoted cell proliferation, invasion and migration and tolerance to chemotherapeutic drugs in vitro. a Expression analyses of Hsp90ab1 mRNA in MGC803 and MKN45 cells after lentivirus-mediated overexpression of Hsp90ab1. b–d Elevated expression of Hsp90ab1 induced significantly higher growth rates, DNA replication and proliferation of MGC803 and MKN45 in GC cells. e The invasion ablity of GC cells was enhanced in Hsp90ab1-overexpressing cells compared with the control groups. f Up-regulation of Hsp90ab1 promoted the migration ability of GC cells. g Growth inhibitory effect of oxaliplatin on Hsp90ab1-overexpressing and empty vector-transfected MGC803 and MKN45 cells. The data was expressed as the mean ± SD and reproduced in three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001