Table 4.
The relapse rate, cumulative dose, treatment success, treatment failure, and side effects of drugs of relapse of the 4 second line drugs.
| Observations | Levamisole |
Cyclophosphamide |
MMF |
Cyclosporine |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1yr Pre |
1 yr During |
1 yr Post |
“P value” | 1yr Pre |
1 yr During |
Post | “P value” | 1yr Pre |
1 yr During |
Post | “P value” | 1yr Pre |
1 yr During |
Post | “P value” | |
| Relapse rate (Relapses/per 1 yr) |
3.6 (0.5) |
1.6 (0.6) |
1.0 (0.9) | <.0001 | 4.0 (0.6) |
1.8 (0.7) |
1.3 (0.8) | <.0001 | 3.9 (0.6) |
1.5 (0.7) |
0.9 (0.8) | <.0001 | 4.1 (0.4) |
1.5 (0.5) |
0.8 (0.7) | <.0001 |
| Cumulative dose of steroids Mg/m2/year |
4100 (1005) | 1700 (650) | 900 (15) | <.0001 | 3900 (950) | 1800 (600) | 920 (18) | <.0001 | 4300 (1010) | 1610 (595) | 850 (20) | <.0001 | 4350 (1100) | 1510 (600) | 705 (25) | <.0001 |
| Treatment success | 12/20 (60%) | 8/12 (66.6%) | 9/15 (60%) | 9/13 (69.2%) | ||||||||||||
| Treatment failure | 2/20 (10%) | 1/12 (8.33%) | 2/15 (13.3%) | 1/13 (7.6%) | ||||||||||||
| Side effects of drugs | 4 patients reversible Neuropenia | 3 patients transient neutropenia 1 hemmorhagic cystitis both improved after stopping drug |
3 patients diarrhea Improved upon stopping MMF |
Mild hirsutism gum- hyperplasia 4 patients mild hypertension |
||||||||||||