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Use-dependent block of INa following acceleration from 1 to 10 Hz in control and after exposure to 0.8 and 1.6 g/L XSN. For control n = 12, 1 Hz n = 7, 10 Hz n = 5. Both of 0.8 and 1.6 g/L XSN in the frequency of 1 or 10 Hz showed significantly use-dependently block of Nav1.5 channel.
