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LINE-1 methylation in mothers of children with DS with congenital heart defects (CHDs) according to World Health Organization (WHO) body mass index (BMI) category.
| WHO-BMI | DNA LINE1 methylation (%) Means | DNA LINE1 methylation, SE | N |
|---|---|---|---|
| 18.5 | 93.77 | 1.87 | 2 |
| 18.5–24.9 | 95.86 | 0.55 | 23 |
| 25–29.9 | 96.08 | 0.76 | 12 |
| ≥30 | 92.50∗ | 1.00 | 7 |
ANOVA P = 0.02; ∗Bonferroni post hoc, BMI ≥ 30 vs. BMI 25–29.9, P = 0.04; BMI ≥ 30 vs. BMI 18.5–24.9, P = 0.03, N = 44.
