Table 3.

LINE-1 methylation in mothers of children with DS with congenital heart defects (CHDs) according to the MTHFR C677T genotype/diet combination.

MTHFR C677T genotype/diet	DNA LINE1 methylation (%) Means	DNA LINE1 methylation SE	N
CC/folate-rich diet	97.69	0.89	9
CT+TT/folate-rich diet	94.94	1.01	7
CC/folate-poor diet	94.68	0.77	12
CT+TT/folate-poor diet	94.55∗	0.67	16

ANOVA P = 0.04, ^∗Bonferroni post hoc CT+TT/folate-poor diet, N = 44.