Table 4.

Multivariate analysis of predictors that influence LINE-1 methylation in mothers of children with DS with congenital heart defects (CHDs).

Predictors included in the analysis	Beta	Standard error of beta	P-level
Currently smoking	0.10	0.16	0.53
Current alcohol intake	0.08	0.15	0.57
Current medication use	−0.20	0.14	0.17
BMI	−0.32	0.14	0.03
Periconceptional folic acid intake	−0.01	0.15	0.96
MTHFR C677T genotype/diet	−0.40	0.15	0.01
Age of mother	−0.22	0.15	0.14

R = 0.58, R² = 0.34, adjusted R² = 0.21, P < 0.028.