Table 7.
Comparison of MTX42h levels in patients with and without hepatotoxicity and distribution with reference to the cycles.
| 2 g/m2 |
Pa | 5 g/m2 |
Pa | |||
|---|---|---|---|---|---|---|
| Hepatotoxicity+ | Hepatotoxicity- | Hepatotoxicity+ | Hepatotoxicity- | |||
| Cycles 1 | 0.29 (0.22–2.02) (n = 8) | 0.80 (0.38–1.06) (n = 6) | >.05 | 0.77 (0.444–1.92) (n = 6) | 0.88 (0.56–1.20) (n = 11) | >.05 |
| Cycles 2 | 0.86 (0.43–1.02) (n = 5) | 0.70 (0.25–0.99) (n = 9) | >.05 | 0.47 (0.28–0.99) (n = 2) | 0.70 (0.44–1,12) (n = 15) | >.05 |
| Cycles 3 | 0.88 (0.31–1.2) (n = 3) | 0.49 (0.26–0.86) (n = 11) | >.05 | 0.37 (0.24–0.90) (n = 2) | 0.68 (0.42–1,09) (n = 15) | >.05 |
| Cycles 4 | 0.94 (0.72–1.1) (n = 2) | 0.40 (0.17–1.06) (n = 12) | >.05 | 0.42 (0.26–1.48) (n = 2) | 0.60 (0.28–0.99) (n = 15) | >.05 |
The first row shows MTX levels at 42 nd h and the second row shows number of patients.
a
Mann Whitney U-test.