Fig. 4.

Mice were given i.p. 10 mg/kg CP154526, a CRF-R1 antagonist (striped), or saline (non-striped) before exposure to TMT (black) or H₂O (white, n = 8/group). Behavioral measures assessed during the pre-test phase were: a contact with the object (s), b time spent in the far corners (s), c defensive burying (s), and d distance traveled (cm). These same variables were measured during the post-test: e contact with object, f time spent in the far corners, g defensive burying, and h distance traveled. i Representative heat maps of time and location of mice after saline and 10 mg/kg CP154526 pretreatment and TMT exposure. The white triangle indicates the location of the stimulus. The legend indicates blue for minimum and red for maximum. **p < 0.01 vs. H₂O, ##p < 0.01 vs. saline