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. 2019 Feb 12;9:1859. doi: 10.1038/s41598-018-38299-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heat map of the interburst period as a function of g_C and g_K. We sample g_C, g_K on a grid with resolution 0.25 nS. For each point, we generate 20 trajectories of duration 2000 s and count the number of bursts in each trajectory. A period of high calcium activity has to last at least 1 second to be considered as a burst. The heat map show the average value of τ_IBI in color log scale for a fixed amount of noise σ = 4 pA ms^1/2. (a) I_ext = −4 pA (noise driven bursting); (b) I_ext = 0 pA (dynamically driven bursting).