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. 2019 Feb 12;10:711. doi: 10.1038/s41467-019-08441-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Representative images and traces for responses measured with cell surface iATPSnFRs. a The upper panels show three examples of ATP responses for HEK293 cells expressing iATPSnFR^1.0. The lower panels show representative traces and an average dose–response curve from 290 cells. b As in (a), but for iATPSnFR^1.1. The dose–response curve represents an average from 191 cells. In the dose–response curves, the error bars represent the s.e.m. and in some cases are smaller than the symbols used for the mean. n numbers are provided in the figure panels and refer to the number of cells