Table 2.
Weight loss and glucose homeostatic parameters before and after surgery.
| SG | RYGB | ||||
|---|---|---|---|---|---|
| Pre-surgery | Post- surgery | Pre- surgery | Post- surgery | Pa | |
| Weight loss period (days) | 19.2 ± 2.5 | 22.8 ± 2.3 | 0.30 | ||
| Total weight loss (%) | 8.9 ± 0.6 | 7.9 ± 0.6 | 0.22 | ||
| Excess weight loss (%) | 21.5 ± 1.6 | 20.1 ± 2.2 | 0.60 | ||
| Change in BMI (kg/m2) | −3.9 ± 0.3 | −3.8 ± 0.4 | 0.80 | ||
| Glucose (mg/dL) | 156.0 ± 18.4 | 116.0 ± 12.1 | 149.7 ± 10.0 | 114.9 ± 7.7* | 0.82 |
| Insulin (uIU/mL) | 37.1 ± 12.5 | 17.7 ± 2.3 | 24.4 ± 3.6 | 17.7 ± 4.0* | 0.27 |
| C-peptide (ng/mL) | 5.3 ± 1.1 | 3.6 ± 0.3 | 4.1 ± 0.3 | 3.6 ± 0.5 | 0.27 |
| HOMA-IR (mmol × uIU × L2) | 14.1 ± 4.8 | 5.2 ± 1.0 | 8.6 ± 1.2 | 5.3 ± 1.6* | 0.25 |
| Insulin clearance, fasting C-peptide/insulin (ng/uIU) | 0.17 ± 0.01 | 0.21 ± 0.01*** | 0.20 ± 0.03 | 0.24 ± 0.03 | 0.94 |
| Si (mL × uU−1 × min−1) | 0.7 ± 0.1 | 1.4 ± 0.2* | 1.2 ± 0.3 | 1.6 ± 0.3 | 0.47 |
| AIR (mL−1 × uU × min) | 38.6 ± 14.4 | 121.5 ± 31.9* | 35.4 ± 14.3 | 150.2 ± 37.7** | 0.43 |
| Acute C-peptide response (%) | 4.0 ± 2.2 | 20.1 ± 6.8* | 7.3 ± 2.6 | 32.2 ± 2.3*** | 0.28 |
| Sg (min−1) | 0.014 ± 0.002 | 0.011 ± 0.002 | 0.013 ± 0.003 | 0.012 ± 0.002 | 0.22 |
| DI | 20.2 ± 7.1 | 163.3 ± 52.7* | 31.2 ± 17.2 | 232.9 ± 64.4* | 0.53 |
Data are presented as mean ± SEM. Pa value for unpaired t-test of between group difference in change from pre- to post-intervention. *P < 0.05, **P < 0.01, ***P < 0.001 within group difference between pre- and post-intervention. Excess Weight Loss (%) calculated using the calculation of ideal body weight as that equivalent to a BMI of 25 kg/m2.