Table 3.
Fasting plasma hormone levels before and after surgery.
| SG | RYGB | ||||
|---|---|---|---|---|---|
| Pre-surgery | Post-surgery | Pre-surgery | Post-surgery | Pa | |
| GLP-1 (pmol/L) | 22.8 ± 2.3 | 19.4 ± 2.1 | 9.3 ± 1.9 | 14.3 ± 3.5 | 0.01 |
| Insulin:GLP1 molar ratio | 14.6 ± 5.9 | 7.9 ± 1.8 | 23.1 ± 5.0 | 12.0 ± 3.2* | 0.41 |
| PYY (pg/mL) | 86.5 ± 23.5 | 72.0 ± 19.2 | 79.0 ± 22.8 | 71.6 ± 17.0 | 0.76 |
| Ghrelin (pg/mL) | 371.7 ± 37.4 | 111.1 ± 8.4*** | 245.5 ± 18.6 | 256.4 ± 26.1 | <0.001 |
| Glucagon (pg/mL) | 101.5 ± 11.8 | 77.3 ± 6.0* | 79.0 ± 11.0 | 86.4 ± 15.0 | 0.03 |
| Insulin:Glucagon molar ratio | 9.4 ± 2.6 | 6.0 ± 0.8 | 7.7 ± 1.1 | 4.8 ± 1.0* | 0.82 |
Data are presented as mean ± SEM. Pa value for unpaired t-test of between group difference in change from pre- to post-intervention. *P < 0.05, **P < 0.01, ***P < 0.001 within group difference between pre- and post-intervention. Samples for measurement of plasma ghrelin were unavailable for 2 RYGB subjects. Outliers identified by ROUT (Q = 1%) were removed for GLP-1 values for 1 subject in each group.