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. 2019 Feb 12;9:1847. doi: 10.1038/s41598-019-38526-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of small molecules 3-aza, L755, B02, and NU7026, and the protein Ad4E1B on HBV replication and CRISPR/Cas9-mediated suppression of HBV in HepG2-1.1merHBV cells. (a–c) Relative levels of pgRNA, (d–f) S-RNA, (g–i) intracellular HBV DNA, and (J-L) cccDNA in HepG2-1.1merHBV cells transfected with CRISPR/Cas9 system and one of the 3 sgRNA (Sp1, Sp2, Sp3), as indicated. Asterisks indicate statistically significant differences. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.