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. 2019 Feb 12;9:1853. doi: 10.1038/s41598-019-38534-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Interferon response signature genes were significantly enriched in niraparib-treated tumors. (A) Tumor growth curve for the SK6005 syngeneic model with control or 50 mg/kg niraparib (QD) treatment. (B) Genes identified with DEseq as significantly upregulated upon niraparib treatment (p <=0.05, fold change >=1.5) were subjected to enrichment analysis of pathway gene sets. Gene Set Enrichment Analysis (GSEA) demonstrated a significant enrichment of interferon gamma signature (C) and interferon alpha signature (D) genes in niraparib-treated samples. (E) Tumor growth curve for the MDA-MB-436 NOG-EXL humanized model treated with control or 35 mg/kg niraparib daily for 5 days on and 2 days off for 4 weeks (QD × 5 × 4). (F) Significantly upregulated genes identified with a two-sample t test (p <=0.05, fold change >=1.5) were subjected to enrichment analysis of pathway gene sets. Gene Set Enrichment Analysis (GSEA) demonstrated a significant enrichment of interferon gamma signature (G) and interferon alpha signature (H) genes in niraparib-treated samples.