Table 2.
Univariate and multivariate Cox-regression results of factors related to overall survival.
| Univariate analysis | Multivariate analysis | ||||||
|---|---|---|---|---|---|---|---|
| Variables | Hazard Ratio (95% CI) | P value | Variables | Hazard Ratio (95% CI) | P value | ||
| Genetic risk score (High risk vs. low risk) | 4.221 | (2.536–7.026) | <0.001 | Genetic risk score (High risk vs. low risk) | 3.402 | (2.873–3.93) | <0.001 |
| Age | 1.025 | (1.007–1.044) | 0.006 | Age | 1.029 | (1.009–1.049) | 0.004 |
| Male gender | 1.264 | (0.805–1.985) | 0.307 | Male gender | 1.062 | (0.598–1.527) | 0.798 |
| AJCC TNM stage | <0.001 | AJCC TNM stage | <0.001 | ||||
| I | 1.000 (reference) | I | 1.000 (reference) | ||||
| II | 1.450 | (0.547–3.845) | II | 1.057 | (0.066–2.048) | ||
| III | 2.820 | (1.090–7.293) | III | 2.082 | (1.115–3.049) | ||
| IV | 6.511 | (2.461–17.225) | IV | 5.733 | (4.739–6.726) | ||
| KRAS mutation | 0.797 | (0.505–1.257) | 0.325 | KRAS mutation | 0.805 | (0.31–1.3) | 0.389 |
| BRAF mutation | 1.257 | (0.692–2.285) | 0.464 | BRAF mutation | 1.327 | (0.504–2.151) | 0.508 |
| MSI-high | 0.800 | (0.422–1.515) | 0.481 | MSI-high | 0.759 | (−0.106–1.6) | 0.526 |
AJCC: American Joint Committee on Cancer; MSI: microsatellite instability.