Table 1.

IC₅₀ of pterosin derivatives against BACE1, AChE, and BChE

Compounds	IC50 (µM)
	BACE1	AChE	BChE
(2S)-Pterosin A	>125	56.7 ± 2.6	67.3 ± 3.3
(2R)-Pterosin B	29.6 ± 3.5	16.2 ± 1.0	48.1 ± 0.59
(2S,3R)-Pterosin C	23.1 ± 2.9	12.8 ± 0.79	44.3 ± 1.0
(2R,3R)-Pterosin C	26.2 ± 6.3	23.2 ± 4.6	20.3 ± 0.88
(3R)-Pterosin D	92.5 ± 7.0	68.7 ± 3.7	>125
(2S)-Pterosin P	67.1 ± 7.7	17.8 ± 0.62	55.9 ± 5.6
Pterosin Z	80.0 ± 5.9	46.5 ± 3.4	80.1 ± 6.8
(2S)-Pteroside A	84.6 ± 6.0	110 ± 3.0	19.4 ± 0.22
(2S)-Pteroside A2	94.4 ± 4.5	39.3 ± 1.9	119 ± 2.5
(2R)-Pteroside B	18.0 ± 2.8	2.55 ± 0.23	62.0 ± 0.71
(2S,3R)-Pteroside C	28.9 ± 2.2	9.17 ± 0.82	13.0 ± 0.14
(2R,3R)-Pteroside C	9.74 ± 1.9	3.77 ± 0.38	5.29 ± 0.82
(3S)-Pteroside D	10.7 ± 1.5	27.4 ± 1.2	19.3 ± 0.17
(2 )-Pteroside P	>125	57.5 ± 3.2	33.2 ± 3.0
Pteroside Z	53.3 ± 1.2	24.1 ± 1.1	5.31 ± 0.19
Quercetina	18.8 ± 1.0
Berberineb		0.39 ± 0.01	3.32 ± 0.12

IC₅₀ values (µM) are expressed as the mean ± S.D. of three experiments

BACE1 β-site amyloid precursor protein cleaving enzyme 1, AChE acetylcholinesterase, BChE butyrylcholinesterase

^aQuercetin and ^bberberine were used as positive controls for the BACE1, AChE, and BChE assays, respectively