. 2019 Feb 12;9:1856. doi: 10.1038/s41598-018-38366-w

Table 1.

Grading of acute and chronic inflammatory response of treatments.

Time Point	Inflammation	Untreated	Matrix Only	Allogeneic	Autologous
2 weeks	Acute	3	3	3	1
2 weeks	Chronic	0	2	2	2
4 weeks	Acute	2	2	3	1
4 weeks	Chronic	1	1	2	1
6 weeks	Acute	1	2	1	0
6 weeks	Chronic	2	1	2	1
8 weeks	Acute	1	0	1	0
8 weeks	Chronic	3	2	2	2

Autologous cell-treated wounds showed minimal signs of acute inflammation at 2 weeks; whereas, the untreated, matrix-treated and allogeneic cell-treated wounds showed dense neutrophilic inflammation and granulation tissue on the surface of the wound at this stage. Chronic inflammation of autologous treatments was less or comparable to other treatments. Chronic inflammation may be associated more with the surgical intervention procedures and not to the treatments.