Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Feb 12;10(2):137. doi: 10.1038/s41419-019-1352-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — miR-642a-5p may mediate a ceRNA network with LINC01234 and SHMT2. a The number of significantly downregulated miRNAs in TCGA COAD is 290. The numbers of predicted miRNAs of LINC01234 is 332 according to LncBase Predicted v.2. The number of experimentally validated miRNAs of SHMT2 is 120 according to TarBase v7.0. The number of overlapped miRNAs in the above three intersections is 2, indicating that LINC01234 and SHMT2 may share 2 common microRNAs with experimental evidence. b The relative expression of miR-642a-5p in colon cancer tissues compared with normal tissue was analyzed using TCGA COAD. c miR-642a-5p expression was analyzed by qRT-PCR in colon cancer tissues and corresponding adjacent nontumor tissues, and the data are presented as 2^-△CT values (n = 20). d LINC01234 expression was analyzed by qRT-PCR in 4 human colon cancer cell lines (HCT116, HT-29, LoVo, and SW480) and normal human colonic epithelial NCM460 cells. e Association analysis of the relationship between miR-642a-5p and LINC01234 expression levels in TCGA COAD. f Association analysis of the relationship between miR-642a-5p and SHMT2 expression levels in TCGA COAD. g Association analysis of the relationship between miR-642a-5p and LINC01234 expression levels in 20 paired colon cancer tissues. h Association analysis of the relationship between miR-642a-5p and SHMT2 expression levels in 20 paired colon cancer tissues. The experiments were performed in triplicate. The data are represented as means ± SD from three independent experiments. *P < 0.05