TABLE 1.
Patient laboratory resultsa
| Parameter | Value(s) |
|||
|---|---|---|---|---|
| Normal range | At time of diagnosis | After 4 wks of induction therapy |
After 8 wks of induction therapy |
|
| Serum | ||||
| Cryptococcal antigen titer | Negative | 1:1,280 | 1:320 | 1:2,560 |
| Creatinine | 0.7–1.30 mg/dl | 0.72 | 1.73 | 1.59 |
| AST | 19–55 U/liter | 33 | 59 | 27 |
| ALT | 19–72 U/liter | 31 | 123 | <8 |
| WBC | 4.5 × 109–11 × 109 cells/liter | 13.3 | 3.9 | 4.5 |
| Platelets | 150 × 109–440 × 109 cells/liter | 254 | 140 | 174 |
| ANC | 2.0 × 109–7.5 × 109 cells/liter | 12.2 | 1.9 | 2.2 |
| ALC | 1.5 × 109–5.0 × 109 cells/liter | 0.6 | 1.3 | 1.7 |
| Absolute CD4 count (%) | 510–2,230 cells/µl (34%–58%) | 228b (38%) | 871 (56%) | |
| Absolute CD8 count (%) | 180–1,520 cells/µl (18%–38%) | 132b (22%) | 358 (23%) | |
| CSF | ||||
| Opening pressure | 27 mm Hg | ND | ND | |
| Cryptococcal antigen | Negative | 1:40 | ND | ND |
| Culture | Negative | Negative | ND | ND |
| Nucleated cells | 0–5/μl | 5 | ND | ND |
| Protein | 15–45 mg/dl | 48 mg/dl | ND | ND |
| Glucose | 50–75 mg/dl | 75 mg/dl | ND | ND |
a
ND, not determined. Data represent patient serum and cerebrospinal fluid (CSF) laboratory results at the time of diagnosis and 4 and 8 weeks after induction therapy. AST, aspartate aminotransferase; ALT, alanine transaminase; WBC, white blood cell count; ANC, absolute neutrophil count; ALC, absolute lymphocyte count.
b
Testing was done three days after initiation of dexamethasone treatment.