FIG 8.

Cartoon of proposed mechanism of regulation of miRNA biogenesis during HSV-1 infection. The cartoon is divided into a nuclear portion to the left and a cytoplasmic portion to the right, with vertical dotted lines representing the nuclear membrane. The upper and lower parts of the cartoon illustrate events occurring during lytic infection and latent infection, respectively. Pre-miRNA stem-loop structures are represented by hairpins. Lines terminating with arrowheads point from causes to results of events, with important factors shown above the arrows and with each red X indicating a loss of expression of important factors. Red lines terminating with perpendicular lines indicate events being blocked by ICP27 and/or lytic products dependent upon ICP27 for their synthesis, with the dashed line indicating a loss of the block.