Fig. 2.

Histological sections of the osteotomy site stained with hematoxylin and eosin. Arrowhead (▼) indicates an interruption of the growth plate. At 2 weeks of treatment, most of the areas at the osteotomy site were filled with fibrous tissues (short arrows) in both the control (A) and LIPUS groups (B). On the other hand, bone to bone bonding (long arrows) was observed in the ALN (C) and ALN + LIPUS groups (D). At 4 weeks of treatment, small amounts of fibrous bonding were observed in the control (E) and LIPUS groups (F). A thicker trabecular bone and dense trabecular bone union were observed in the ALN (G) and ALN + LIPUS groups (H). LIPUS, low-intensity pulsed ultrasound; ALN, alendronate.