Table 4.

Percentage of Runx2-positive cells at the osteotomy site of the proximal tibia.

Runx2-positive cell (%)	Control	LIPUS	ALN	ALN + LIPUS	Two-factor factorial ANOVA
					LIPUS	ALN	Interaction
2 Weeks	1.86 ± 1.69	1.89 ± 1.75	2.69 ± 1.16	4.20 ± 1.22	NS	P = 0.011	NS
4 Weeks	1.63 ± 0.43	1.89 ± 0.11	3.63 ± 0.22a	3.46 ± 0.28b	NS	P < 0.001	NS

Values are presented as the mean ± standard deviation.

Runx2, runt-related transcription factor 2; LIPUS, low-intensity pulsed ultrasound; ALN, alendronate.

Control, saline + sham LIPUS; LIPUS, saline + LIPUS; ALN, alendronate + sham LIPUS; ALN + LIPUS, alendronate + LIPUS; NS, not significant.

^aP < 0.001 and ^bP < 0.05 vs. control group by 2-way analysis of variance (ANOVA) using Dunn post hoc test.