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. 2019 Feb 6;10:154. doi: 10.3389/fimmu.2019.00154

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Copyright © 2019 Legroux, Moratalla, Laurent, Deblois, Verstraeten and Arbour.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased levels of soluble MULT1 in the CSF during EAE. Quantification of soluble MULT1 in CSF from Klrk1^−/− (black bars) and wild type counterparts (Klrk1^+/+; white bars) either injected with CFA-PBS as control (Ctl) or subjected to active EAE and sacrificed at pre-symptomatic (presympt), onset or peak stage of the disease. (A) One representative western blot for the detection of total protein and MULT1. (B) Quantification of 55 kDa and 25 kDa forms as relative expression compared to total protein; levels in Klrk1^+/+ at disease peak defined as 1. Mean ± SEM n = 3–4. (C) Ratio of the 25 kDa/55 kDa forms at disease peak. Mean ± SEM n = 4.