Table 1.
miRNAs Differentially Expressed in 34 T-ALL Samples and Controls
| miRNA_ID | Average Read Counts |
log FC | P adj | |||
|---|---|---|---|---|---|---|
| All Samples |
Control |
T-ALL |
||||
| Raw | Normalized | Normalized | Normalized | |||
| miRNAs overexpressed in T-ALL vs. controls | ||||||
| hsa-miR-548a-3p | 21.2 | 20.1 | 0.0 | 23.0 | 7.674 | 8.27E-05 |
| hsa-miR-128-3p | 457,447.9 | 382,618.6 | 61,129.6 | 429,896.4 | 2.814 | 9.22E-05 |
| hsa-miR-181b-5p | 51,636.7 | 45,642.4 | 6860.0 | 51,345.7 | 2.904 | 1.28E-04 |
| hsa-miR-20b-5p | 3524.9 | 3005.6 | 296.2 | 3404.1 | 3.522 | 4.28E-04 |
| hsa-miR-6500-3p | 61.2 | 53.2 | 1.5 | 60.7 | 5.220 | .002 |
| hsa-miR-331-5p | 160.5 | 134.1 | 34.7 | 148.7 | 2.100 | .004 |
| hsa-miR-363-3p | 41,814.5 | 35,610.7 | 5759.5 | 40,000.6 | 2.796 | .008 |
| hsa-miR-153-3p | 71.8 | 51.4 | 0.0 | 59.0 | 9.031 | .008 |
| hsa-miR-466 | 127.4 | 112.5 | 0.0 | 129.1 | 10.157 | .009 |
| hsa-miR-130a-3p | 524.9 | 419.1 | 106.2 | 465.1 | 2.130 | .009 |
| hsa-miR-20b-3p | 65.1 | 58.7 | 7.9 | 66.2 | 3.053 | .010 |
| hsa-miR-210-3p | 508.4 | 460.4 | 75.8 | 517.0 | 2.766 | .010 |
| hsa-miR-181a-3p | 5371.8 | 4663.6 | 851.3 | 5224.2 | 2.617 | .010 |
| hsa-miR-4421 | 27.9 | 23.9 | 0.0 | 27.4 | 7.928 | .011 |
| hsa-miR-18b-5p | 15.8 | 11.9 | 0.0 | 13.6 | 6.937 | .012 |
| hsa-miR-181a-2-3p | 7392.8 | 6055.4 | 1753.8 | 6687.9 | 1.931 | .015 |
| hsa-miR-181a-5p | 159,408.7 | 146,775.2 | 31,833.1 | 163,678.4 | 2.362 | .015 |
| hsa-miR-625-3p | 3238.1 | 2702.5 | 638.3 | 3006.1 | 2.236 | .018 |
| hsa-miR-130b-3p | 381.5 | 337.0 | 109.9 | 370.4 | 1.753 | .025 |
| hsa-miR- 4687-5p | 26.9 | 24.8 | 1.6 | 28.2 | 4.070 | .035 |
| hsa-miR-4437 | 98.4 | 90.7 | 15.7 | 101.8 | 2.686 | .039 |
| hsa-miR-625-5p | 912.2 | 765.9 | 214.4 | 847.0 | 1.982 | .039 |
| hsa-miR-3609 | 993.4 | 1843.8 | 79.5 | 2103.2 | 4.723 | .041 |
| miRNAs underexpressed in T-ALL vs. controls | ||||||
| hsa-miR-574-5p | 652.8 | 542.1 | 3554.4 | 99.1 | −5.164 | 2.88E-19 |
| hsa-miR-10a-5p | 5025.9 | 4115.7 | 22,247.8 | 1449.2 | −3.940 | 5.11E-13 |
| hsa-miR-582-3p | 493.6 | 406.7 | 2490.7 | 100.3 | −4.633 | 4.16E-12 |
| hsa-miR-143-3p | 7581.1 | 6131.8 | 33,787.1 | 2064.9 | −4.032 | 1.51E-11 |
| hsa-miR-941 | 10,845.5 | 9357.4 | 34,576.7 | 5648.6 | −2.614 | 2.00E-09 |
| hsa-miR-145-5p | 75.5 | 63.8 | 364.7 | 19.5 | −4.212 | 2.87E-07 |
| hsa-miR- 27a-5p | 1526.9 | 1226.4 | 4706.0 | 714.6 | −2.719 | 1.04E-06 |
| hsa-miR-618 | 107.4 | 95.3 | 575.4 | 24.6 | −4.543 | 1.11E-06 |
| hsa-miR-24- 3p | 4801.6 | 4038.7 | 12,326.8 | 2819.9 | −2.128 | 2.39E-06 |
| hsa-miR-574- 3p | 75.1 | 65.3 | 325.6 | 27.0 | −3.587 | 2.43E-06 |
| hsa-miR-24-2-5p | 191.9 | 160.0 | 484.9 | 112.2 | −2.109 | 3.00E-06 |
| hsa-miR-145-3p | 76.8 | 66.7 | 330.4 | 27.9 | −3.568 | 5.64E-06 |
| hsa-miR-504-5p | 48.6 | 41.1 | 238.1 | 12.2 | −4.278 | 8.27E-05 |
| hsa-miR- 3690 | 50.4 | 46.9 | 223.2 | 21.0 | −3.409 | 2.45E-04 |
| hsa-miR- 223-5p | 6511.1 | 5472.8 | 18,853.6 | 3505.1 | −2.427 | 2.50E-04 |
| hsa-miR-199b-5p | 1728.1 | 1309.1 | 5169.0 | 741.4 | −2.801 | .001 |
| hsa-miR-550a-5p | 132.9 | 111.0 | 411.6 | 66.7 | −2.621 | .001 |
| hsa-miR-4695-3p | 3.6 | 3.3 | 25.6 | 0.0 | −7.824 | .001 |
| hsa-miR-30a-5p | 412.6 | 346.1 | 808.7 | 278.1 | −1.539 | .001 |
| hsa-miR-3909 | 176.9 | 149.9 | 365.8 | 118.2 | −1.625 | .002 |
| hsa-miR-2115-3p | 28.5 | 22.9 | 128.9 | 7.3 | −4.103 | .002 |
| hsa-miR-582-5p | 25.4 | 20.3 | 122.3 | 5.3 | −4.495 | .002 |
| hsa-miR-504-3p | 1.6 | 1.2 | 9.5 | 0.0 | −6.412 | .002 |
| hsa-miR- 23a-5p | 28.9 | 24.9 | 98.1 | 14.1 | −2.784 | .003 |
| hsa-miR-10b-5p | 211.4 | 146.8 | 629.1 | 75.9 | −3.047 | .006 |
| hsa-miR-4494 | 1.1 | 0.8 | 6.3 | 0.0 | −5.825 | .007 |
| hsa-miR-151a-3p | 2930.2 | 1886.3 | 6696.9 | 1178.8 | −2.506 | .009 |
| hsa-miR- 223-3p | 3083.8 | 2647.2 | 7802.3 | 1889.1 | −2.046 | .011 |
| hsa-miR-6865-3p | 0.7 | 0.6 | 4.5 | 0.0 | −5.331 | .012 |
| hsa-miR-7849-3p | 2.0 | 1.6 | 12.2 | 0.0 | −6.764 | .012 |
| hsa-miR- 1275 | 505.7 | 440.2 | 1198.6 | 328.6 | −1.866 | .012 |
| hsa-miR-338-5p | 38.7 | 32.3 | 128.7 | 18.1 | −2.821 | .013 |
| hsa-miR-3150b-5p | 1.1 | 0.9 | 6.3 | 0.1 | −4.945 | .016 |
| hsa-miR-3154 | 74.1 | 62.4 | 242.6 | 35.9 | −2.752 | .017 |
| hsa-miR-6823-5p | 0.6 | 0.4 | 3.4 | 0.0 | −4.956 | .017 |
| hsa-miR-10a- 3p | 12.8 | 10.5 | 48.4 | 4.9 | −3.273 | .024 |
| hsa-miR-143-5p | 16.6 | 13.1 | 75.6 | 3.9 | −4.234 | .036 |
| hsa-miR-4745-3p | 1.1 | 1.0 | 7.8 | 0.0 | −6.125 | .036 |
Controls, normal mature T lymphocytes of bone marrow donors aged <18 years; Average Read Counts Normalized, average TMM normalized reads; FC, fold change; P adj, Benjamini and Hochberg correction for multiple testing and .05 significance level. miRNAs are sorted based on increasing P adj values and decreasing log FC values.