. 2019 Jan 31;21(1):78–90. doi: 10.5853/jos.2018.02369

Table 1.

Study design and characteristics of included studies in our meta-analysis

Study	Country	Study design, registry	No. of patients	BP monitoring	sICH definitions used	Adjusted variables	Outcomes
Ahmed et al. (2009) [22]	Multinational	Retrospective, SITS-ISTR (2002–2007)	11,080	Admission: 24 hr after IVT	SITS-MOST	Age, sex, weight, OTT, baseline NIHSS, glucose, and imaging, vascular risk factors, anti-HTN and antiplatelet medication, functional independence	2, 4^*
Delgado-Mederos et al. (2008) [24]	Spain	Prospective	80	Admission: 24 hr after IVT	-	Baseline NIHSS, vascular risk factors, occlusion site, anti-HTN treatment	2, 5^†
Endo et al. (2013) [24]	Japan	Retrospective, SAMURAI rt-PA	527	Admission: 24 hr after IVT	ECASS 2	Age, sex, baseline NIHSS, OTT, vascular risk factors, anti-HTN treatment prior to IVT, ASPECTS	1, 3, 4^*
Huang et al. (2013) [25]	China	Retrospective	101	Admission: IVT	ECASS 2	Baseline NIHSS and serum glucose, DM, leukoaraiosis	1^†
Huang et al. (2013) [25]							1^*
Idicula et al. (2008) [26]	Norway	Prospective	127	Admission: 24 hr after IVT	-	Age, sex, baseline NIHSS, vascular risk factors	2^*
Kellert et al. (2012) [27]	Germany	Retrospective	427	Admission: 24 hr after IVT	ECASS 2	-	3^†
Kellert et al. (2017) [28]	Multinational	Prospective, SITS-ISTR (2002–2013)	16,434	Admission: 24 hr after IVT	ECASS 2 SITS-MOST	Age, sex, baseline NIHSS, vascular risk factors, SBP	1, 2, 3, 4^*
Lindsberg et al. (2003) [29]	Finland	Retrospective	75	Admission: 24 hr after IVT	-	-	2^†
Lindsberg et al. (2003) [29]							2^*
Liu et al. (2016) [30]	China	Retrospective	461	Admission: 24 hr after IVT	ECASS 2	Age, sex, baseline NIHSS, OTT, glucose, vascular risk factors	3^†
Liu et al. (2016) [30]							1, 3^*
Martins et al. (2016) [31]	Portugal	Retrospective	674	Admission: 24 hr after IVT	NINDS	Age, sex, baseline NIHSS, Endovascular therapy, vascular risk factors, SBP	3^*
Menon et al. (2012) [32]	Multinational	Prospective	10,242	Admission: 24 hr after IVT	NINDS	Age, sex, race, baseline NIHSS, SBP, glucose	3^*
Molina et al. (2004) [33]	Multinational	Prospective, CLOTBUST	177	Admission: IVT	ECASS 2	-	2^†
Molina et al. (2004) [33]							2^*
Molina et al. (2009) [34]	Multinational	RCT, TUCSON	35	Admission: 36 hr after IVT	SITS-MOST	Age, sex, OTT, baseline NIHSS	1, 2, 3, 4, 5^†
Molina et al. (2009) [34]							1, 2, 4^*
Rusanen et al. (2015) [35]	Finland	Retrospective	104	Admission: IVT	-	Age, sex, baseline NIHSS, OTT, vascular risk factors, occlusion site	2^*
Saqqur et al. (2008) [36]	Multinational	Retrospective	349	Admission: 24 hr after IVT	ECASS 3	Age, sex, baseline NIHSS, glucose, SBP, OTT	3^†
Saqqur et al. (2008) [36]							3^*
Tomii et al. (2011) [37]	Japan	Prospective	125	Admission: 24 hr after IVT	-	Age, baseline NIHSS, vascular risk factors, eGFR	2^*
Toni et al. (2012) [38]	Italy	Retrospective, SITS-ISTR (2002–2010)	3,246	Admission: 24 hr after IVT	SITS-MOST	Age, sex, baseline NIHSS, glucose, BP, OTT, vascular risk factors, functional independence	2, 3^*
Tsivgoulis et al. (2007) [7]	Multinational	Retrospective, CLOTBUST	351	Admission: 2 hr after IVT	ECASS 3	Age, sex, OTT, baseline NIHSS and serum glucose	1, 2, 3, 4, 5^†
Tsivgoulis et al. (2007) [7]							1, 2, 3, 4, 5^*
Tsivgoulis et al. (2009) [6]	USA	Retrospective	510	Admission: IVT	ECASS 3	Age, sex, OTT, baseline NIHSS, vascular risk factors and medications	3^†
Tsivgoulis et al. (2009) [6]							3^*
Wahlgren et al. (2008) [8]	Multinational	Prospective, SITS-MOST (2002–2006)	6,483	Admission: IVT	SITS-MOST	Age, sex, weight, ASPECTS, baseline NIHSS and glucose, vascular risk factors and medications, SBP, functional independence	2, 3, 4^*
Waltimo et al. (2016) [39]	Finland	Retrospective	1,868	Admission: 48 hr after IVT	ECASS 2, NINDS, SITS-MOST	Age, SBP, baseline NIHSS, glucose and ASPECTS	3^*
Wu et al. (2017) [40]	China	Retrospective	420	Admission: IVT	-	Age, sex, BMI, baseline NIHSS, OTT, SBP, vascular risk factors	2^†
Wu et al. (2017) [40]							2^*
Wu et al. (2016) [41]	China	Prospective, TIMS-CHINA	1,128	Admission: 24 hr after IVT	NINDS	Age, sex, baseline NIHSS, ASPECTS, OTT, aspirin use	1, 2, 3^*
Yan et al. (2015) [42]	China	Retrospective	161	Admission: 2 hr after IVT	ECASS 2	Vascular risk factors	5^†
Yong et al. (2005) [43]	Multinational	Post hoc RCT, ECASS	615	Admission: 72 hr after IVT	-	Age, sex, weight, baseline SSS, OTT, aspirin use, ASPECTS, vascular risk factors	1^†
Yong et al. (2008) [44]	Multinational	Post hoc RCT, ECASS 2	793	Admission: 24 hr after IVT	-	Age, sex, baseline SSS, OTT, aspirin use, ASPECTS, vascular risk factors	1, 4^*

(1) Favorable functional outcome (modified Rankin Scale [mRS] 0–1), (2) functional independence (mRS 0–2), (3) sICH, (4) mortality, (5) recanalization.

BP, blood pressure; sICH, symptomatic intracranial hemorrhage; SITS-ISTR, Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register; IVT, intravenous thrombolysis; SITS-MOST, Safe Implementation of Thrombolysis in Stroke-Monitoring Study; OTT, onset-to-treatment; NIHSS, National Institutes of Health Stroke Scale; HTN, hypertension; SAMURAI rt-PA, Stroke Acute Management with Urgent Risk-factor Assessment and Improvement recombinant tissue plasminogen activator; ECASS, European Cooperative Acute Stroke Study; ASPECTS, Alberta stroke program early CT score; DM, diabetes mellitus; SBP, systolic blood pressure; NINDS, National Institute of Neurological Disorders and Stroke; CLOTBUST, Combined Lysis of Thrombus in Brain ischemia using transcranial Ultrasound and Systemic tPA; RCT, randomized controlled trial; TUCSON, transcranial ultrasound in clinical sonothrombolysis; eGFR, estimated glomerular filtration rate; BMI, body mass index; TIMS-CHINA, thrombolysis implementation and monitor of acute ischemic stroke in China; SSS, Scandinavian Stroke Scale.

Adjusted multivariable data;

^†

Unadjusted descriptive data.