Table 2.

Overview of primary and secondary analyses of pre-treatment BP impact on various outcomes

Clinical outcome	BP level	Unadjusted analyses				Adjusted analyses*
		Studies	SMD (95% CI)	P	Heterogeneity	Studies	OR (95% CI)	P	Heterogeneity
FFO	SBP	5	–0.18 (–0.40 to 0.04)	0.120	I2=76%, P for Cochran Q=0.002	8	0.91 (0.87 to 0.95)	<0.001	I2=29%, P for Cochran Q=0.19
	DBP	4	–0.01 (–0.11 to 0.10)	0.900	I2=17%, P for Cochran Q=0.30	2	1.00 (0.89 to 1.14)	0.950	I2=0%, P for Cochran Q=0.75
FI	SBP	7	–0.17 (–0.34 to 0.01)	0.060	I2=61%, P for Cochran Q=0.02	6	0.91 (0.84 to 0.98)	0.010	I2=47%, P for Cochran Q=0.09
	DBP	6	0.11 (–0.10 to 0.33)	0.300	I2=49%, P for Cochran Q=0.08	3	1.36 (0.82 to 2.26)	0.230	I2=64%, P for Cochran Q=0.06
sICH	SBP	6	0.24 (0.04 to 0.43)	0.020	I2=37%, P for Cochran Q=0.16	8	1.08 (1.01 to 1.16)	0.020	I2=82%, P for Cochran Q <0.001
	DBP	4	0.11 (–0.03 to 0.24)	0.120	I2=0%, P for Cochran Q=0.83	1	0.99 (0.73 to 1.34)	0.950	-
Mortality	SBP	3	0.17 (–0.09 to 0.44)	0.200	I2=60%, P for Cochran Q=0.08	5	1.02 (0.99 to 1.05)	0.140	I2=0%, P for Cochran Q=0.86
	DBP	2	–0.00 (–0.06 to 0.06)	0.990	I2=0%, P for Cochran Q=0.83	2	0.86 (0.66 to 1.13)	0.280	I2=0%, P for Cochran Q=0.79
Recanalization	SBP	3	–0.21 (–0.41 to –0.01)	0.040	I2=0%, P for Cochran Q=0.94	2	0.47 (0.12 to 1.83)	0.280	I2=73%, P for Cochran Q =0.05
	DBP	2	–0.30 (–0.67 to 0.06)	0.110	I2=0%, P for Cochran Q=0.82	1	0.90 (0.54 to 1.52)	0.700	-

BP, blood pressure; SMD, standardized mean difference; CI, confidence interval; OR, odds ratio; FFO, favorable functional outcome (modified Rankin Scale [mRS] 0–1); SBP, systolic blood pressure; DBP, diastolic blood pressure; FI, functional independence (mRS 0–2); sICH, symptomatic intracranial hemorrhage.

^*In the adjusted for potential confounders analyses all associations of SBP/DBP with the outcomes of interest are presented per 10 mm Hg SBP/DBP increment.