S1.

Univariate analysis of predictive factors associated with overall survival (OS) and disease-free survival (DFS)

Variables	OS			DFS
	HR(95%CI)	P		HR(95%CI)	P
Gender
Male/Famale	1.010 (0.551–1.851)	0.974		0.814 (0.456–1.454)	0.487
Age (year)
> 50/≤ 50	0.878 (0.586–1.316)	0.529		0.821 (0.561–1.200)	0.309
Tumor size (cm)
> 5/≤ 5	3.284 (1.884–5.723)	< 0.001		2.989 (1.827–4.892)	< 0.001
Tumor number
Multiple/Solitary	1.460 (0.925–2.305)	0.104		1.892 (1.238–2.894)	0.003
Tumor differentiation
Poorly/Well or moderately	1.411 (0.950–2.095)	0.088		1.234 (0.849–1.794)	0.271
Cirrhosis
Yes/No	0.993 (0.648–1.523)	0.976		1.109 (0.740–1.662)	0.617
Portal hypertension
Yes/No	1.221 (0.614–2.427)	0.570		1.252(0.651–2.409)	0.501
MVI
Yes/no	3.035 (1.870–4.924)	<0.001		2.775 (1.736–4.437)	<0.001
Alcohol
Yes/no	0.878 (0.550–1.402)	0.586		0.765 (0.492–1.188)	0.233
Shock
Yes/no	1.606 (0.990–2.606)	0.055		1.417 (0.887–2.265)	0.145
Preoperative TAE
Yes/no	0.767 (0.427–1.377)	0.375		1.129 (0.673–1.896)	0.646
Preoperative blood loss (mL)
> 600/≤ 600	0.935 (0.628–1.393)	0.743		0.933 (0.642–1.356)	0.716
BT in hospital
Yes/no	1.594 (1.053–2.412)	0.027		1.570 (1.062–2.323)	0.024
Cholesterin (mmol/L)
> 3.7/≤ 3.7	1.040 (0.697–1.551)	0.848		0.982 (0.672–1.435)	0.924
Creatinine (μmol/L)
> 104/≤ 104	1.465 (0.459–4.670)	0.519		1.236 (0.388–3.935)	0.720
ALT (U/L)
> 40/≤ 40	0.755 (0.489–1.165)	0.204		0.913 (0.611–1.364)	0.657
AST (U/L)
> 40/≤ 40	1.395 (0.940–2.071)	0.099		1.554 (1.068–2.259)	0.021
Continued