2.

Univariate and multivariate analyses of clinical parameters on OS in patients with EGFR muttaions.

Factor	Univariate analysis				Multivariate analysis
	HR (log rank)	95% CI	P		HR (log rank)	95% CI	P
HR: hazard ratio; CI: confidence interval; *: Sensitizing mutations include EGFR exon 19 deletion and L858R; rare mutations include EGFR mutations except exon 19 deletion and L858R.
Gender (male/female)	0.990	0.404–2.413	0.982		1.904	0.541–6.695	0.316
Age, years (≥ 65/<65)	1.221	0.494–3.096	0.656		1.098	0.431–2.795	0.845
Smoking (smoking/never)	1.339	0.523–3.425	0.544		1.988	0.557–7.095	0.290
Lymph node metastases (yes/no)	1.591	0.679–4.113	0.279		1.544	0.587–4.060	0.579
PD-L1 expression (yes/no)	2.339	0.992–9.385	0.057		2.995	1.097–8.178	0.032
CD8 expression (yes/no)	0.409	0.185–1.246	0.138		0.296	0.080–1.103	0.070
EGFR (rare/sensitizing)*	1.279	0.343–5.025	0.693		1.451	0.389–5.408	0.579
KRAS (mutation/wild type)	1.089	0.135–8.839	0.934		1.357	0.132–13.978	0.798