S1.

Search strategies included: PubMed and EMBASE (date was from the inception through June 2017)

1) PubMed search strategy

1. "Lung neoplasms" [Mesh]

2. Lung cancer [Title/Abstract]

3. Lung tumor [Title/Abstract]

4. Lung tumour [Title/Abstract]

5. Lung carcinoma* [Title/Abstract]

6. Lung neoplas* [Title/Abstract]

7. Lung malignan* [Title/Abstract]

8. "B7-H1 antigen" [Mesh]

9. "CD274 protein" [Mesh]

10. PD-L1 [Title/Abstract]

11. PDL1 [Title/Abstract]

12. B7-H1 [Title/Abstract]

13. CD274 [Title/Abstract]

14. "EGFR gene" [Mesh]

15. "erbB1 gene" [Mesh]

16. EGFR [Title/Abstract]

17. TKI [Title/Abstract]

18. EGFR Tyrosine kinase inhibitor [title/Abstract]

19. (1 OR 2 OR 3 OR 4 OR 5 OR 6 OR 7) AND (8 OR 9 OR 10 OR 11 OR 12 OR 13) AND (14 OR 15 OR 16 OR 17 OR 18)

2) EMBASE search strategy

1. 'lung neoplasm'/exp

2. lung cancer:ab,ti

3. lung tumor:ab,ti

4. lung tumour:ab,ti

5. lung carcinoma:ab,ti

6. lung neoplas*:ab,ti

7. lung malignan*:ab,ti

8. lung adenoma*:ab,ti

9. 'B7-H1 antigen'/exp

10. B7-H1

11. 'CD274 protein'/exp

12. CD274

13. 'PD-L1 expression'/exp

14. PDL1 expression:ab,ti

15. 'EGFR'/exp

16. 'TKI'/exp

17. 'EGFR-TKI'/exp

18. EGFR:ab,ti

19. TKI:ab,ti

20. EGFR tyrosine kinase inhibitor:ab,ti

21. (1 OR 2 OR 3 OR 4 OR 5 OR 6 OR 7 OR 8) AND (((9 OR 10) OR (11 OR 12)) OR 13 OR 14) AND (15 OR 16 17 OR 18 OR 19 OR 20)