Table 2.
Basal data potentially influencing antibiotic selection: patient’s characteristics, comorbidities (present in >9% patients), type of infection and severity. Data expressed as n (%) or mean ± SD
| Total (n=133) | Daptomycin (n=62) | Vancomycin (n=71) | p | |
|---|---|---|---|---|
| Males | 85 (63.9) | 44 (71.0) | 41 (57.7) | 0.113 |
| Age | 68.5 ± 15.2 | 67.9 ± 14.9 | 69.1 ± 15.4 | 0.656 |
| ≥65 years | 87 (65.4) | 40 (64.5) | 47 (66.2) | 0.839 |
| Congestive heart failure | 36 (27.1) | 16 (25.8) | 20 (28.2) | 0.760 |
| Diabetes mellitus (DM) | 27 (20.3) | 12 (19.4) | 15 (21.1) | 0.800 |
| COPDa | 23 (17.3) | 8 (12.9) | 15 (21.1) | 0.211 |
| Acute myocardial infarction | 20 (15.0) | 5 (8.1) | 15 (21.1) | 0.036 |
| Malignancies | 23 (17.3) | 9 (14.5) | 14 (19.7) | 0.429 |
| Dementia | 17 (12.8) | 5 (8.1) | 12 (16.9) | 0.128 |
| Stroke | 16 (12.0) | 3 (4.8) | 13 (18.3) | 0.017 |
| DM with organ lesion | 13 (9.8) | 9 (14.5) | 4 (5.6) | 0.085 |
| Hypertension | 12 (9.0) | 9 (14.5) | 3 (4.2) | 0.039 |
| Basal GFRb (mL/min/1.73 m2) | 63.5 ± 31.5 | 59.5 ± 31.2 | 67.2 ± 31.5 | 0.183 |
| Basal GFRb ≤50 mL/min/1.73 m2 | 49 (36.8) | 26 (41.9) | 23 (32.4) | 0.255 |
| Basal creatinine (mg/dL) | 1.0 ± 0.4 | 1.1 ± 0.4 | 1.0 ± 0.4 | 0.036 |
| Basal creatinine ≥0.9 mg/dL | 71 (53.4) | 40 (64.5) | 31 (43.7) | 0.017 |
| Basal creatinine >1.2 mg/dL | 40 (30.1) | 23 (37.1) | 17 (23.9) | 0.099 |
| Basal creatinine clearance (mL/min) | 78.9 ± 37.4 | 73.8 ± 33.1 | 83.1 ± 40.4 | 0.242 |
| Basal creatinine clearance <80 mL/min | 84 (63.2) | 43 (69.4) | 41 (57.7) | 0.166 |
| Basal CPKc (U/L) | 155.0 ± 363.6 | 134.6 ± 196.2 | 171.9 ± 460.2 | 0.666 |
| Osteoarticular infection | 31 (23.3) | 19 (30.6) | 12 (16.9) | 0.061 |
| Skin & Soft tissue infection | 29 (21.8) | 16 (25.8) | 13 (18.3) | 0.296 |
| Catheter-related bacteremia | 26 (19.5) | 11 (17.7) | 15 (21.1) | 0.623 |
| Endocarditis | 17 (12.8) | 12 (19.4) | 5 (7.0) | 0.034 |
| Primary bacteremia | 15 (11.3) | 2 (3.2) | 13 (18.3) | 0.006 |
| Intraabdominal infection | 6 (4.5) | 1 (1.6) | 5 (7.0) | 0.215 |
| Respiratory infection | 4 (3.0) | 0 (0.0) | 4 (5.6) | 0.124 |
| Urinary tract infection | 7 (5.3) | 2 (3.2) | 5 (7.0) | 0.448 |
| Others | 11 (8.3) | 5 (8.1) | 6 (8.5) | 0.936 |
| Sepsis | 97 (72.9) | 43 (69.4) | 54 (76.1) | 0.778 |
| Severe sepsis | 16 (12.0) | 9 (14.5) | 7 (9.9) | 0.410 |
| Shock | 5 (3.8) | 3 (4.8) | 2 (2.8) | 0.663 |
a
COPD: Chronic obstructive pulmonary disease
b
GFR: Glomerular filtration rate
c
CPK: Creatine phosphokinase