Table 3.
Basal data potentially influencing development of nephrotoxicity: patient’s characteristics, comorbidities (present in >9% patients), type of infection and severity. Data expressed as n (%) or mean ± SD
| Nephrotoxicity |
||||
|---|---|---|---|---|
| Total (n=133) | YES (n=21) | NO (n=112) | p | |
| Males | 85 (63.9) | 10 (47.6) | 75 (67.0) | 0.090 |
| Age | 68.5 ± 15.2 | 75.9 ± 8.3 | 67.2 ± 15.8 | 0.001 |
| ≥65 years | 87 (65.4) | 19 (90.5) | 68 (60.7) | 0.009 |
| Congestive heart failure | 36 (27.1) | 10 (47.6) | 26 (23.2) | 0.021 |
| Diabetes mellitus (DM) | 27 (20.3) | 5 (23.8) | 22 (19.6) | 0.768 |
| COPDa | 23 (17.3) | 5 (23.8) | 18 (16.1) | 0.363 |
| Acute myocardial infarction | 20 (15.0) | 4 (19.0) | 16 (14.3) | 0.522 |
| Malignancies | 23 (17.3) | 1 (4.8) | 22 (19.6) | 0.039 |
| Dementia | 17 (12.8) | 3 (14.3) | 14 (12.5) | 0.733 |
| Stroke | 16 (12.0) | 5 (23.8) | 11 (9.8) | 0.134 |
| DM with organ lesion | 13 (9.8) | 4 (19.0) | 9 (8.0) | 0.126 |
| Hypertension | 12 (9.0) | 1 (4.8) | 11 (9.8) | 0.690 |
| Basal GFRb (mL/min/1.73 m2) | 63.5 ± 31.5 | 63.9 ± 32.4 | 61.2 ± 25.8 | 0.738 |
| Basal GFRb ≤50 mL/min/1.73 m2 | 49 (36.8) | 8 (38.1) | 41 (36.6) | 0.896 |
| Basal creatinine (mg/dL) | 1.0 ± 0.4 | 1.0 ± 0.4 | 1.2 ± 0.4 | 0.085 |
| Basal creatinine ≥0.9 mg/dL | 71 (53.4) | 16 (76.2) | 55 (49.1) | 0.022 |
| Basal creatinine >1.2 mg/dL | 40 (30.1) | 13 (61.9) | 27 (24.1) | <0.001 |
| Basal creatinine clearance (mL/min) | 78.9 ± 37.4 | 83.0 ± 38.9 | 52.7 ± 19.9 | <0.001 |
| Basal creatinine clearance <80 mL/min | 84 (63.2) | 19 (90.5) | 65 (58.0) | 0.005 |
| Basal CPKc (U/L) | 155.0 ± 363.6 | 165.0 ± 395.9 | 104.1 ± 82.5 | 0.599 |
| Osteoarticular infection | 31 (23.3) | 5 (23.8) | 26 (23.2) | 1.000 |
| Skin & Soft tissue infection | 29 (21.8) | 4 (19.0) | 25 (22.3) | 1.000 |
| Catheter-related bacteremia | 26 (19.5) | 2 (9.5) | 24 (21.4) | 0.367 |
| Endocarditis | 17 (12.8) | 5 (23.8) | 12 (10.7) | 0.146 |
| Primary bacteremia | 15 (11.3) | 1 (4.8) | 14 (12.5) | 0.464 |
| Intraabdominal infection | 6 (4.5) | 1 (4.8) | 5 (4.5) | 1.000 |
| Respiratory infection | 4 (3.0) | 1 (4.8) | 3 (2.7) | 0.501 |
| Urinary tract infection | 7 (5.3) | 2 (9.5) | 5 (4.5) | 0.305 |
| Others | 11 (8.3) | 1 (4.8) | 10 (8.9) | 1.000 |
| Sepsis | 97 (72.9) | 15 (71.4) | 82 (73.2) | 0.865 |
| Severe sepsis | 16 (12.0) | 4 (19.0) | 12 (10.7) | 0.281 |
| Shock | 5 (3.8) | 1 (4.8) | 10 (8.9) | 1.000 |
a
COPD: Chronic obstructive pulmonary disease
b
GFR: Glomerular filtration rate
c
CPK: Creatine phosphokinase