Table 4.
Basal data potentially influencing development of nephrotoxicity for patients treated with vancomycin: patient’s characteristics, comorbidities (present in >9% patients), type of infection and severity. Data expressed as n (%) or mean ± SD
| Nephrotoxicity |
|||
|---|---|---|---|
| YES (n=17) | NO (n=54) | p | |
| Males | 8 (47.1) | 33 (61.1) | 0.306 |
| Age | 75.8 ± 8.0 | 67.0 ± 16.6 | 0.004 |
| ≥65 years | 15 (88.2) | 32 (59.3) | 0.039 |
| Congestive heart failure | 10 (58.8) | 10 (18.5) | 0.004 |
| Diabetes mellitus (DM) | 3 (17.6) | 12 (22.2) | 1.000 |
| COPDa | 4 (23.5) | 11 (20.4) | 0.745 |
| Acute myocardial infarction | 4 (23.5) | 11 (20.4) | 0.745 |
| Malignancies | 1 (5.9) | 13 (24.1) | 0.162 |
| Dementia | 3 (17.6) | 9 (16.7) | 1.000 |
| Stroke | 5 (29.4) | 8 (14.8) | 0.278 |
| DM with organ lesion | 2 (11.8) | 2 (3.7) | 0.241 |
| Hypertension | 0 (0.0) | 3 (5.6) | 1.000 |
| Basal GFRb (mL/min/1.73 m2) | 66.3 ± 25.5 | 67.4 ± 33.2 | 0.910 |
| Basal GFRb ≤50 mL/min/1.73 m2 | 5 (29.4) | 18 (33.3) | 0.763 |
| Basal creatinine (mg/dL) | 1.1 ± 0.4 | 0.9 ± 0.3 | 0.100 |
| Basal creatinine ≥0.9 mg/dL | 12 (70.6) | 19 (35.2) | 0.010 |
| Basal creatinine >1.2 mg/dL | 7 (41.2) | 7 (13.0) | 0.030 |
| Basal creatinine clearance (mL/min) | 54.1 ± 22.4 | 89.7 ± 40.8 | 0.003 |
| Basal creatinine clearance <80 mL/min | 15 (88.2) | 26 (48.1) | 0.035 |
| Basal CPKc (U/L) | 104.1 ± 82.5 | 200.9 ± 547.9 | 0.549 |
| Osteoarticular infection | 4 (23.5) | 8 (14.8) | 0.463 |
| Skin & Soft tissue infection | 3 (17.6) | 10 (18.5) | 1.000 |
| Catheter-related bacteremia | 2 (11.8) | 13 (24.1) | 0.496 |
| Endocarditis | 3 (17.6) | 2 (3.7) | 0.085 |
| Primary bacteremia | 1 (5.9) | 12 (22.2) | 0.167 |
| Intraabdominal infection | 1 (5.9) | 4 (7.4) | 1.000 |
| Respiratory infection | 1 (5.9) | 3 (5.6) | 1.000 |
| Urinary tract infection | 2 (11.8) | 3 (5.6) | 0.587 |
| Others | 1 (5.9) | 5 (9.3) | 1.000 |
| Sepsis | 12 (70.6) | 42 (77.8) | 0.532 |
| Severe sepsis | 3 (17.6) | 4 (7.4) | 0.346 |
| Shock | 1 (5.9) | 1 (1.9) | 0.424 |
a
COPD: Chronic obstructive pulmonary disease
b
GFR: Glomerular filtration rate
c
CPK: Creatine phosphokinase