Table 5.
Basal data potentially influencing development of nephrotoxicity for patients treated with daptomycin: patient’s characteristics, comorbidities (present in >9% patients), type of infection and severity. Data expressed as n (%) or mean ± SD
| Nephrotoxicity |
|||
|---|---|---|---|
| YES (n=4) | NO (n=58) | p | |
| Males | 2 (50.0) | 42 (72.4) | 0.573 |
| Age | 76.0 ± 10.8 | 67.3 ± 15.1 | 0.209 |
| ≥65 years | 4 (100) | 36 (62.1) | 0.287 |
| Congestive heart failure | 0 (0.0) | 16 (27.6) | 0.565 |
| Diabetes mellitus (DM) | 2 (50.0) | 10 (17.2) | 0.166 |
| COPDa | 1 (25.0) | 7 (12.0) | 0.433 |
| Acute myocardial infarction | 0 (0.0) | 5 (8.6) | 1.000 |
| Malignancies | 0 (0.0) | 9 (15.5) | 1.000 |
| Dementia | 0 (0.0) | 5 (8.6) | 1.000 |
| Stroke | 0 (0.0) | 3 (5.2) | 1.000 |
| DM with organ lesion | 2 (50.0) | 7 (12.1) | 0.097 |
| Hypertension | 1 (25.0) | 8 (13.8) | 0.475 |
| Basal GFRb (mL/min/1.73 m2) | 37.0 ± 7.0 | 60.7 ± 31.6 | 0.085 |
| Basal GFRb ≤50 mL/min/1.73 m2 | 4 (100) | 23 (39.7) | 0.031 |
| Basal creatinine (mg/dL) | 1.5 ± 0.4 | 1.1 ± 0.4 | 0.061 |
| Basal creatinine ≥0.9 mg/dL | 4 (100) | 36 (62.1) | 0.287 |
| Basal creatinine >1.2 mg/dL | 3 (75.0) | 20 (34.5) | 0.139 |
| Basal creatinine clearance (mL/min) | 48.4 ± 11.7 | 75.8 ± 33.4 | 0.170 |
| Basal creatinine clearance <80 mL/min | 4 (100) | 39 (67.2) | 0.302 |
| Basal CPKc (U/L) | 186.2 ± 240.2 | 134.6 ± 199.2 | 1.000 |
| Osteoarticular infection | 1 (25.0) | 18 (31.0) | 1.000 |
| Skin & Soft tissue infection | 1 (25.0) | 15 (25.9) | 1.000 |
| Catheter-related bacteremia | 0 (0.0) | 11 (19.0) | 1.000 |
| Endocarditis | 2 (50.0) | 10 (17.2) | 0.166 |
| Primary bacteremia | 0 (0.0) | 2 (3.4) | 1.000 |
| Intraabdominal infection | 0 (0.0) | 1 (1.7) | 1.000 |
| Respiratory infection | 0 (0.0) | 0 (0.0) | - |
| Urinary tract infection | 0 (0.0) | 2 (3.4) | 1.000 |
| Others | 0 (0.0) | 5 (8.6) | 1.000 |
| Sepsis | 3 (75.0) | 40 (69.0) | 1.000 |
| Severe sepsis | 1 (25.0) | 8 (13.8) | 0.475 |
| Shock | 0 (0.0) | 3 (5.2) | 1.000 |
a
COPD: Chronic obstructive pulmonary disease
b
GFR: Glomerular filtration rate
c
CPK: Creatine phosphokinase