Japuntich 2006

Methods	Setting: clinic/internet, USA Recruitment: community volunteers
Participants	284 smokers (≥ 10 cigs/day); 55% female, average age 41, average cigs/day 22
Interventions	All participants received bupropion (300 mg) for 9 weeks, 3 brief (20 mins) individual counselling sessions, 5 clinic visits for assessment, monthly assessment calls 1. Access to Comprehensive Health Enhancement Support System for Smoking Cessation and Relapse Prevention (CHESS SCRP) for 12 weeks, computer and access provided, daily use recommended, reminders to log on up to 3 times a week 2. No additional support
Outcomes	Abstinence at 6 months (PP) Validation: CO ≤ 10 ppm
Notes	New for 2009 update 12‐month follow‐up results not published
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomisation method not described
Allocation concealment (selection bias)	Unclear risk	No details given
Blinding of participants and personnel (performance bias) All outcomes	Low risk	No details given, but as support provided to both groups pre‐intervention, and not during intervention period, performance bias unlikely
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Biochemical validation used
Incomplete outcome data (attrition bias) All outcomes	Low risk	20% losses to follow‐up and intervention participants who didn't get computer included in ITT analysis