Table 3.
Univariable Cox regression analysis
| Parameter | Overall survival | Recurrence-free survival | ||
|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Age (years at diagnosis) | ||||
| < 73 | 1 | 0.001 | 1 | 0.009 |
| ≥73 | 2.533 (1.466–4.377) | 2.194 (1.216–3.958) | ||
| Gender | ||||
| Male | 1 | 0.462 | 1 | 0.634 |
| Female | 0.839 (0.524–1.341) | 0.881 (0.523–1.484) | ||
| T-stage | ||||
| T3 | 1 | 0.003 | 1 | 0.002 |
| T4 | 2.68 (1.409–5.128) | 2.982 (1.503–5.915) | ||
| Malignancy grade | ||||
| Medium/Low | 1 | 0.536 | 1 | 0.636 |
| Higha | 1.159 (0.726–1.852) | 1.134 (0.675–1.906) | ||
| Localisation | ||||
| Right | 1 | 0.792 | 1 | 0.150 |
| Left | 1.084 (0.594–1.981) | 1.576 (0.848–2.927) | ||
| Tumour perforation | ||||
| No | 1 | 0.001 | 1 | 0.005 |
| Yes | 5.332 (1.924–14.776) | 5.644 (1.708–18.645) | ||
| Lymph nodes | ||||
| < 12 nodes | 1 | 0.440 | 1 | 0.220 |
| ≥12 nodes | 1.203 (0.753–1.922) | 1.386 (0.823–2.334) | ||
| Perineural invasion | ||||
| No | 1 | 0.630 | 1 | 0.873 |
| Yes | 1.417 (0.343–5.857) | 0.850 (0.117–6.203) | ||
| Vascular invasion | ||||
| No | 1 | 0.878 | 1 | 0.756 |
| Yes | 0.922 (0.332–2.566) | 0.830 (0.256–2.690) | ||
| PD-L1 | ||||
| Low | 1 | 0.748 | 1 | 0.258 |
| High | 1.104 (0.604–2.016) | 1.429 (0.769–2.653) | ||
Univariable Cox regression analysis regarding overall survival and recurrence-free survival for the sub-cohort of patients with MSI tumours (N = 172). Statistically significant p-values are highlighted in bold
aIncluding mucinous adenocarcinomas and signet-ring cell carcinomas
MSI microsatellite instability