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. 2019 Feb 12;38:72. doi: 10.1186/s13046-019-1068-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Expression of DRAM2 in non-small cell lung cancer (NSCLC). a. DRAM2 protein expression analyzed by immunohistochemistry in (a) alveolar and (b) normal bronchial epithelial cells; (c) squamous cell carcinoma and (d) adenocarcinoma. Magnification, × 200. b. Relative expression of DRAM2 mRNA in 20 pairs of NSCLC samples and adjacent normal lung tissues.DRAM2 overexpressed in NSCLC samples and have statistical significance,p = 0.0466. c. Western blot showing the detection of DRAM2 and p53 in the lysates of 15 paired tumor (C) and adjacent normal tissues (N). β-actin was used as a loading control. The results were quantified using ImageLab, and intensity values were normalized to the β-actin band.The relative expression was quantified below