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. 2019 Feb 12;38:72. doi: 10.1186/s13046-019-1068-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Overexpression of p53 restrained the effects of DRAM2 on cell migration and proliferation. a. MTT assay; b. Colony formation assay; c. Transwell migration were performed in the context of DRAM2 overexpression and downregulation in H661 cells. Only colony formation assay for both downregulated p53 and DRAM2 have statistical significance,p = 0.0482. d. Effects of DRAM2 levels on the expression of proteins associated with cell proliferation, migration, and p53 in transfected H661 cells