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. 2019 Feb 12;20:9. doi: 10.1186/s12865-019-0289-9

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Detection of anti-Aβ antibodies by ELISA and determination of Aβ-specific T cell responses by ELISPOT (a) Serum antibody concentrations of mice immunized four times with four types of Aβ1–6 chimeric protein vaccines were detected by ELISA. Serum antibody concentrations were relatively determined according to the standard curve based on 6E10. (b) Spleen cells isolated from immunized mice were stimulated with Aβ1–42 peptide. (c) Spleen cells were stimulated with wild-type NoV P particles. **P < 0.01, ***P < 0.001, NS = no significant difference