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. 2019 Feb 13;17:12. doi: 10.1186/s12964-019-0322-x

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — LDR suppresses the thyroid cancer carcinogenesis through STAT3-miR-330-5p axis. During thyroid cell malfunction, miR-144-3p/miR-330-5p degrades the PAX8 mRNA levels, thereby blocks its activity to NIS, TG and TSHR promoters. However, LDR treatment decreases the PAX8 targeting miRNAs expression and eventually recovers the PAX8 activity on its target gene promotes to improve thyroid cell function in cancer cells