Table 3.
Significantly Different, Nonsteroid Metabolites Within the Lipid Superpathway, Between Groups
| Superpathway | Subpathway | Biochemical Name | Groups | |||
|---|---|---|---|---|---|---|
| Infertility vs Spontaneous | IVF vs Spontaneous a | NIFT vs Spontaneous | IVF vs NIFT | |||
| Lipid | Fatty acid metabolism (acyl choline) | Palmitoylcholine | 1.50a | 1.74 | 1.02 | 1.70a |
| Lipid | Fatty acid metabolism (acyl choline) | Oleoylcholine | 1.49a | 1.74 | 0.97 | 1.79a |
| Lipid | Fatty acid metabolism (acyl choline) | Dihomo-linolenoyl-choline | 1.82a | 2.13 | 1.19 | 1.80a |
| Lipid | Fatty acid metabolism (acyl choline) | Linoleoylcholine | 1.38a | 1.58 | 0.97 | 1.63a |
| Lipid | Fatty acid metabolism (acyl choline) | Stearoylcholine | 1.50a | 1.78 | 0.94 | 1.90a |
| Lipid | Fatty acid metabolism (acyl choline) | Docosahexaenoylcholineb | 1.65a | 1.93 | 1.08 | 1.79a |
| Lipid | Fatty acid metabolism (acyl choline) | Arachidonoylcholine | 1.48a | 1.74 | 0.97 | 1.80a |
| Lipid | Phosphatidylinositol | 1,2-Dipalmitoyl-GPI (16:0/16:0) | 1.65a | 1.94 | 1.07 | 1.81c |
| Lipid | Phosphatidylinositol | 1-Palmitoyl-2-oleoyl-GPI (16:0/18:1) | 1.16c | 1.24 | 1.01 | 1.23c |
| Lipid | Phosphatidylinositol | 1-Palmitoyl-2-arachidonoyl-GPI (16:0/20:4) | 1.23a | 1.33 | 1.03 | 1.29c |
| Lipid | Phosphatidylinositol | 1-Stearoyl-2-oleoyl-GPI (18:0/18:1) | 1.10 | 1.16 | 0.99 | 1.18c |
| Lipid | Phosphatidylethanolamine | 1,2-Dipalmitoyl-GPE (16:0/16:0) | 1.29c | 1.38 | 1.12 | 1.23 |
| Lipid | Phosphatidylethanolamine | 1-Palmitoyl-2-docosahexaenoyl-GPE (16:0/22:6)b | 1.25a | 1.30 | 1.14 | 1.13 |
| Lipid | Phosphatidylethanolamine | 1-Stearoyl-2-docosahexaenoyl-GPE (18:0/22:6)b | 1.32a | 1.38 | 1.18c | 1.17 |
| Lipid | Phosphatidylethanolamine | 1-Oleoyl-2-docosahexaenoyl-GPE (18:1/22:6)b | 1.24a | 1.29 | 1.14 | 1.14 |
| Lipid | Diacylglycerol | Stearoyl-arachidonoyl-glycerol (18:0/20:4) [1]d | 1.14 | 1.25 | 0.93 | 1.34a |
| Lipid | Diacylglycerol | Stearoyl-arachidonoyl-glycerol (18:0/20:4) [2]d | 1.10 | 1.20 | 0.90 | 1.34a |
| Lipid | Diacylglycerol | Oleoyl-arachidonoyl-glycerol (18:1/20:4) [1]d | 1.19c | 1.27 | 1.01 | 1.26c |
| Lipid | Diacylglycerol | Oleoyl-arachidonoyl-glycerol (18:1/20:4) [2]d | 1.19c | 1.29 | 1.00 | 1.28c |
| Lipid | Diacylglycerol | Linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]d | 1.23a | 1.30 | 1.09 | 1.20 |
| Lipid | Diacylglycerol | Linoleoyl-docosahexaenoyl-glycerol (18:2/22:6)b [2]d | 1.46c | 1.59 | 1.20 | 1.33 |
Fold changes of members in the subpathways of acyl cholines, phosphatidylinositol, phosphatidylethanolamine, and DAG between the following groups: infertility vs spontaneous, the IVF vs spontaneous, NIFT vs spontaneous, and IVF vs NIFT. Analysis of covariance was performed using BMI as a covariate.
a
P < 0.05.
b
Contains the DHA acyl chain.
c
0.05 < P < 0.1.
d
Isomer.